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CAS 107868-30-4 Anabolic Steroid Hormone Exemestane Aromasin Exemestan Bulking Cycle Steroids
CAS No:107868-30-4
Alias: Aromasin ; Exemestan , Exemestane
Molecular Formula: C20H24O2
Assay: 97.0%~103.0%
Purity: 99%
MF: C20H24O2
MW: 296.4
Appearance: White or almost White Crystalline Powder.
Pharmacokinetics
Exemestane is quickly absorbed from the gut, but undergoes a strong first-pass effect in the liver. Highest blood plasma concentrations are reached after 1.2 hours in breast cancer patients and after 2.9 hours in healthy subjects. Maximal aromatase inhibition occurs after two to three days.90% of the absorbed substance are bound to plasma proteins. The liver enzyme CYP3A4 oxidizes the methylidene group in position 6, and the 17-keto group (on the five-membered ring) is reduced by aldo-keto reductases to an alcohol. Of the resulting metabolites, 40% are excreted via the urine and 40% via the feces within a week. The original substance accounts for only 1% of excretion in the urine. The terminal half-life is 24 hours
Performance enhancement
Exemestane has been used in doping to raise luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels, which in turn increases the ratio of male over female sexual hormones and so improves performance. The drug also counteracts gynecomastia as well as fat and water retention following excessive aromatase production due to testosterone doping.
Is exemestane the same as tamoxifen?
Whereas tamoxifen interferes with the ability of breast cancer cells to use estrogen for growth, exemestane interferes with the body's ability to make estrogen. Exemestane inactivates the enzyme aromatase, which the body uses to make estrogen
What kind of steroid is exemestane?
Exemestane is an oral steroidal aromatase inhibitor used in the adjuvant treatment of hormonally-responsive (also called hormone-receptor-positive, estrogen-responsive) breast cancer in postmenopausal women.
What is the drug exemestane used for?
Exemestane is used to treat early breast cancer in women who have experienced menopause ('change of life'; end of monthly menstrual periods) and who have already been treated with a medication called tamoxifen (Nolvadex) for 2 to 3 years
How long should you take exemestane for?
People being treated for primary breast cancer will usually take exemestane for five to ten years. Some people start taking exemestane after a few years of taking the hormone therapy drug tamoxifen
What are the benefits of taking exemestane?
Exemestane, a synthetic steroid drug widely prescribed to fight breast cancers that thrive on estrogens, not only inhibits the production of the hormone, but also appears to protect cells throughout the body against damage induced by UV radiation, inflammation and other assaults
What is Aromasin?
Aromasin ) lowers estrogen levels in postmenopausal women, which may slow the growth of certain types of breast tumors that need estrogen to grow in the body.
Aromasin is used to treat early and advanced breast cancer in postmenopausal women. Early breast cancer is cancer that has not spread outside the breast. Advanced breast cancer is cancer that has spread to other parts of the body.
COA
TEST ITEMS | SPECIFICATION | RESULTS |
Description | White Crystalline Powder | White Powder |
Identification | Positive | Positive |
Assay(by HPLC) | 98.0~102.0% | 98.64% |
Absorbance(E1cm) | 465~495 | 482.5 |
Melting Point | 191~195°C | 193.5~195.0°C |
Loss On Drying | 0.5%max | 0.19% |
Specific Rotation | +288°~ +298° | +290.2° |
Residue On Ignition | 0.1%max | 0.03% |
Related Substances | Total:1.5%max | <1.3% |
Single:0.5%max | <0.4% | |
Residue Solvents | 0.2%max | 0.10% |
Heavy Metals | 20PPm max | <10PPm |
Conclusion | The specification conform with enterprise standard. |
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