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Insulin-like growth factor IGF-1 LR3

Advantages of IGF-1 LR3:

1. Increase the use of adults as the main source of energy to achieve the effect of fat loss.

2. Contribute to anti-aging.

3. Increase efficiency of nutrient transport utilization (e.g. protein synthesis)

4. Increase the ability of nerve cell repair and regeneration.

5. Increase the ability of cell fiber proliferation, so that you have fuller muscles.

Physiology of IGF-1

IGF-1, also known as Somatomedin-C, is a peptide growth factor. There are many tissues in the body that can produce IGF-1, but the main source is the liver. The liver synthesizes and secretes IGF-1 under the stimulation and control of growth hormone.

Growth hormone (GH) is secreted by the anterior pituitary gland, and its main function is to control the growth of internal cells, bones and muscles and maintain the normal function of organs.

The secreted GH enters the blood, is absorbed by the liver after a few minutes, and then converted into different growth factors, the most important of which is "insulin-like growth factor" (IGF-1; Insulin-like growth factor 1) . Almost all the functions of growth hormone, including promoting bone growth, synthesizing protein, increasing muscle tissue, reducing trace amounts, lowering cholesterol, regulating glucose, and insulin, must be completed under the synergistic promotion of IGF-1. So some people compare IGF-1. It is a "channel" (channel), because many other hormones must also cooperate with IGF-1, that is, they must first pass through this "channel" before they can perform their normal functions.

What is the difference in the mechanism of action of IGF-1 and IGF-1 LR3 in the body?

As mentioned above, IGF-1 is a growth factor similar in structure to several insulins. After the secretion of these hormones from the pituitary gland, these hormones are transmitted from the hypothalamus through neurotransmitters to stimulate the liver to produce IGF-1.

While IGF-1 LR3 is contained on proteins that play an important role in mammalian growth and development, IGF1 LR3 (insulin growth factor-1 long arginine 3) insulin-like growth factor-1-long chain arginine-3 also Known as the IGF. IGF1 LR3 is also known as long R3 IGF-1 or IGF-I-Arg-Arg3.

LR3 IGF-1 is more effective than conventional IGF-1, because IGF-1 LR3 and pure IGF have a listed binding rate of binding binding proteins, which usually inhibit the biological effects of IGF, so IG-1 LR3 and IGF Classification has been shown to have better efficacy and functionality.

IGF-1 extended IGF-1 LR3 analogs were generated to increase the biological activity of the IGF peptide.

This is a human recombinant aglycosylated chain IGF1 LR3 containing 83 amino acids and having a molecular weight of 9200. Also known as long R3 IGF-1 or IGF-I-Arg-Arg3. MIM 139250) promotes many growth effects, and IGF-1 LR3 is a long-chain analogue of human IGF-1, designed and manufactured specifically for mammalian cell culture to support large-scale production of drugs. Earlier studies showed that growth hormone did not directly stimulate the entry of sulfate into the blood plasma, or through serum factors called "sulfated factors," which were later called "growth factors."

When used together with steroids, IGF-1 will enhance the stimulation intensity of steroids (with the ability to increase satellite cells), physical performance, and the user's strength and endurance a lot.

The most potent form of IGF-1 is believed to be IGF-1 LR3. The structure has been chemically changed and binds to proteins in the human body and increases the half-life, staying in the human body for up to about 20-30 hours.

Association of IGF-1 LR3 and muscle growth

IGF-1 LR3 is designed to increase the biological activity of IGF peptides, the most active of which are to increase the utilization efficiency of amino acids, glucose, promote protein synthesis and reduce protein breakdown. In the part of energy conversion, IGF-1 LR3 reduces energy production as much as possible in adult tissue, while in muscle tissue, IGF-1 LR3 can prevent insulin from transporting glucose on the cell membrane, and increase protein synthesis and amino acid absorption. So the cells have to switch to burning poorly for energy.

IGF-1 LR3 builds new muscle cells by promoting nitrogen retention and protein synthesis, causing muscle growth through hyperplasia (an increase in the number of muscle cells) and mitosis (the actual growth of new muscle fibers). Therefore, IGF-1 LR3 not only increases the size of muscle fibers (Hypertrophy) but also increases the number of muscle cells (Hyperplasia) and is more effective in muscle growth than steroids. Taken together, IGF can alter the heritability of muscle tissue and cell count, increasing and differentiating the number and types of cells present.

The half-life of IGF-1 LR3 and its effect on IGF-1

IGF-1 LR3 has a much longer half-life than other forms, almost 20-30 hours. When IGF-1 LR3 is active, it has multiple effects on tissue in muscle cells, and IGF-1 LR3 promotes the increase and division of stem cells. IGF-1 LR3 increases satellite cell activity (enhanced steroid stimulation), muscle DNA, muscle protein content, muscle weight and muscle cross-sectional area; the advantage of IGF-1 LR3 is that it can significantly promote muscle growth. Combined with weight training, steroid use, these effects are significantly enhanced.

Chemical Information of IGF-1 LR3:

Molecular weight: 9117.5 g/mol

Molecular formula: C400H625N111O115S9

CAS number: 946870-92-4

Amino acid sequence: Met-Phe-Pro-Ala-Met-Pro-Leu-Ser-Ser-Leu-Phe-Val-Asn-Gly-Pro-Arg-Thr-Leu-Cys-Gly-Ala-Glu-Leu -Val-Asp-Ala-Leu-Gln-Phe-Val-Cys-Gly-Asp-Arg-Gly-Phe-Tyr-Phe-Asn-Lys-Pro-Thr-Gly-Tyr-Gly-Ser-Ser-Ser -Arg-Arg-Ala-Pro-Gln-Thr-Gly-Ile-Val-Asp-Glu-Cys-Cys-Phe-Arg-Ser-Cys-Asp-Leu-Arg-Arg-Leu-Glu-Met-Tyr -Cys-Ala-Pro-Leu-Lys-Pro-Ala-Lys-Ser-Ala

IGF-1 side effects

Athletes and bodybuilders often achieve enhanced muscle growth, strength, and endurance through the use of such drugs, including growth hormone (GH), IGF-1, steroids, selective androgen receptor modulators (SARMS), and others.

IGF-1 LR3 can increase anabolic capacity, and many fitness websites and peptide (peptide) studies have shown that peptide hormone injections can affect the endocrine system and metabolism. Although IGF-1LR3 can lower blood sugar, because IGF-1 can promote the growth of all cell tissues, it will also enhance the growth of tumor cells. In addition, headache is one of the common side effects of injecting IGF-1 LR3.

Application of IGF-1 in anti-aging

IGF-1 has become the focus of many researchers, considering it as the most important "youth-promoting factor" stimulated by growth hormone (GH). Because so far, no substance has been found that can slow down the process of human lifespan more than IGF-1. The researchers found that appropriate IGF-1 concentrations can replace all exacerbated symptoms, allowing people to live longer, healthier, and more energetic lives. Because IGF-1 can condense loose muscles, reduce the weight of adults, and help rebuild muscles, bones, and nerve cells.

Although IGF-1 has so many benefits, unfortunately, after everyone is over 30 years old, the secretion of GH is significantly reduced. IGF-1 is affected by the reduction of GH, and the synthesis of IGF-1 is also reduced. Studies have found that after the age of 21 to 31, the secretion of GH decreases by about 14% every ten years. Therefore, at the age of 30, it is only half of that of young people, and at the age of 80, it is only one-fifth of that of young people.

Published research reports have shown that the imbalance of IGF-1 in the body is easily related to the following diseases, including prostate cancer, infertility, post-traumatic stress, and difficulty in recovery after surgery and trauma. Therefore, the measurement of IGF-1 concentration in the blood of middle-aged and elderly people has at least the following evaluation benefits from the perspective of preventing old age:

1. Assess the ability to maintain bone density.

2. The ability to prevent the decline of nerve cells (the ability to fight against unresponsiveness).

3. Evaluate the state of physical decline and recovery ability that may be caused by trauma or stress.

4. The ability to resist muscle looseness and maintain muscle elasticity.

5. The ability to keep the skin bright and lustrous.

6. The ability to reduce the chance of cardiovascular disease (slowing down the substitution of steroids).

Summarizing the above points, the effects that IGF-1 can provide:

1. Increase the use of adults as the main source of energy to achieve the effect of fat loss.

2. Contribute to rejuvenation.

3. Increase efficiency of nutrient transport utilization (e.g. protein synthesis)

4. Increase the ability of nerve cell repair and regeneration.

5. Increase the ability of cell fiber proliferation, so that you have fuller muscles

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